Who We Are

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The CoSAGE Project was designed to closely connect the community and campus so that we can move quickly between the discovery of new knowledge and development of tailored interventions (See Figure below). Specifically, the CoSAGE research structure (See Figure below) includes MSU-based resources to store and analyze biologic, health, life-style, and environmental data (Genomics Core and Analysis Core). The MSU-based resources are linked to our community partners through a community-based health data collection core (Phenotyping Core) and two community committees: the Research Advisory Committee (RAC) and the Research Ethics Committee (REC). As new data and information are generated through the CoSAGE research studies, the RAC, EC, and MSU researchers work together to analyze, interpret, and prioritize the next steps (Translation Core). The next steps may include either translating research findings into community and individual interventions or conducting more research. We expect the CoSAGE structure and partnership approach will yield a rapid turnaround to tailored interventions that impact key outcomes at both the community level (e.g. county-level risk assessment, improved county health indices, tailored policy making, tailored resource planning) and individual level (e.g. increased knowledge, increased healthy behaviors, decreased disease and symptom burden, increased quality of life).

 

 

Learn more about the The CoSAGE Project Cores below.

Administrative Core

The goal of the campus and community-based CoSAGE Administrative Core is to oversee and administer the overall project, including 1) provide scientific leadership, 2) establish and facilitate community partnerships, 3) build research networks at MSU, 4) establish and maintain community committees and external advisory boards, 5) achieve long-term sustainability of the partnership, and 6) conduct formative and summative evaluations.

Phenotyping Core

A primary and ongoing goal of the community-based CoSAGE Phenotyping Core is to conduct community assessments in order to identify and prioritize health needs in the community. Another goal of the Phenotype Core is to develop the processes for recruiting individuals into the Community Assessment and Research Participant Registry as the foundation for future health or health problem-specific studies.

Genotyping Core

The overall goals of the campus-based CoSAGE Genotype Core are to receive, process, and store biologic samples to support the scientific goals of gene discovery.  The primary use of the biologic samples is to isolate DNA to determine the sequence at specific genes (i.e. the genotype).

Analysis Core

The campus-based CoSAGE Analysis Core provides the critical link between the biologic, genealogical, and phenotype (health information) data to conduct the statistical analysis required to answer our research questions. A secure database structure is housed on the MSU campus to support our ability to enter, manage, store, retrieve and analyze data in a manner that protects the privacy and confidentiality of our research participants.

Translational Core

The community-based CoSAGE Translational Core provides the essential venue for the joint analysis and interpretation of study results between the Community Research Advisory Committe, Community Research Ethics Committee, and MSU research partners towards the goal of improving health in the partner community. The Translation Core provides loops the research process back into the community for the purposes of either conducting more research or developing and testing community-tailored health innovation.